Journal article
Multicenter Australian trial of islet transplantation: Improving accessibility and outcomes
PJ O'Connell, DJ Holmes-Walker, D Goodman, WJ Hawthorne, T Loudovaris, JE Gunton, HE Thomas, ST Grey, CJ Drogemuller, GM Ward, DJ Torpy, PT Coates, TW Kay
American Journal of Transplantation | WILEY-BLACKWELL | Published : 2013
DOI: 10.1111/ajt.12250
Abstract
Whilst initial rates of insulin independence following islet transplantation are encouraging, long-term function using the Edmonton Protocol remains a concern. The aim of this single-arm, multicenter study was to evaluate an immunosuppressive protocol of initial antithymocyte globulin (ATG), tacrolimus and mycophenolate mofetil (MMF) followed by switching to sirolimus and MMF. Islets were cultured for 24 h prior to transplantation. The primary end-point was an HbA1c of 0.2 nmol/L had cessation of severe hypoglycemia. Nine of the 17 recipients tolerated switching from tacrolimus to sirolimus with similar graft outcomes. There was a small but significant reduction in renal function in the firs..
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Funding Acknowledgements
This study was funded by a grant from the Department of Health and Ageing, Commonwealth of Australia and administered by the Juvenile Diabetes Research Foundation. The assistance of the following people in establishing this program is acknowledged: R Ayala-Perez, H Burns, L Elkerbout, E Estella, D Gregory, J Hawkes, K Hor, J-Q Huang, A Irvin, R Jones, C Kos, J Kuehlich, C Liddle, R MacIssac, K-W Ng, N Sanders, A Webster, G Wong.