Journal article
Quantitative Guidelines for the Prediction of Ultrasound Contrast Agent Destruction During Injection
G Threlfall, HJ Wu, K Li, B Aldham, J Scoble, ID Šutalo, A Raicevic, L Pontes-Braz, B Lee, M Schneider-Kolsky, A Ooi, G Coia, R Manasseh
Ultrasound in Medicine and Biology | Published : 2013
Abstract
Experiments and theory were undertaken on the destruction of ultrasound contrast agent microbubbles on needle injection, with the aim of predicting agent loss during invivo studies. Agents were expelled through a variety of syringe and needle combinations, subjecting the microbubbles to a range of pressure drops. Imaging of the bubbles identified cases where bubbles were destroyed and the extent of destruction. Fluid-dynamic calculations determined the pressure drop for each syringe and needle combination. It was found that agent destruction occurred at a critical pressure drop that depended only on the type of microbubble. Protein-shelled microbubbles (sonicated bovine serum albumin) were v..
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Funding Acknowledgements
Brian Lee was funded by an arrangement between Primary Healthcare and CSIRO. B.L. is grateful to Paul Tauro of Primary Healthcare for his support and encouragement and to Morry Silberstein at Monash University for support and advice. Our experiment was initiated after discussions on animal experiments with Karlheinz Peter, Ingo Ahrens and Xiaowei Wang at Baker-IDI. We are grateful to Muthupandian Ashokkumar and Franz Grieser at the University of Melbourne for the initial advice and to Erik Gelderblom of the University of Twente for the initial experiments on proteinaceous microbubble preparation.