Angiotensin type 1A receptors transfected into the nucleus tractus solitarii of AT1a-/- mice increase blood pressure and cardiovascular responses to aversive stress

Abstract

We examined the effect of expression of angiotensin type 1A (AT 1A ) receptors in neurons in the nucleus tractus solitarii (NTS) of AT 1A −/− mice on basal blood pressure (BP) and cardiovascular responses to stress. Bilateral microinjections of lentivirus with the phox2a‐responsive promoter PRSx8 of either green fluorescent protein (GFPv, n=8) or AT 1A receptors (AT 1A v, n=6) were made into the NTS of AT 1A −/− mice fitted with telemetry devices for BP re..