Retinoic acid expression associates with enhanced IL-22 production by gamma delta T cells and innate lymphoid cells and attenuation of intestinal inflammation
Lisa A Mielke, Sarah A Jones, Mathilde Raverdeau, Rowan Higgs, Anna Stefanska, Joanna R Groom, Alicja Misiak, Lara S Dungan, Caroline E Sutton, Gundula Streubel, Adrian P Bracken, Kingston HG Mills
Journal of Experimental Medicine | ROCKEFELLER UNIV PRESS | Published : 2013
Retinoic acid (RA), a vitamin A metabolite, modulates mucosal T helper cell responses. Here we examined the role of RA in regulating IL-22 production by γδ T cells and innate lymphoid cells in intestinal inflammation. RA significantly enhanced IL-22 production by γδ T cells stimulated in vitro with IL-1β or IL-18 and IL-23. In vivo RA attenuated colon inflammation induced by dextran sodium sulfate treatment or Citrobacter rodentium infection. This was associated with a significant increase in IL-22 secretion by γδ T cells and innate lymphoid cells. In addition, RA treatment enhanced production of the IL-22-responsive antimicrobial peptides Reg3β and Reg3γ in the colon. The attenuating effect..View full abstract
This work was supported by a Science Foundation Ireland Strategic Research Cluster grant and a Principal Investigator Award to K.H.G. Mills.