Journal article
Levetiracetam-loaded biodegradable polymer implants in the tetanus toxin model of temporal lobe epilepsy in rats
AJ Halliday, TE Campbell, TS Nelson, KJ McLean, GG Wallace, MJ Cook
Journal of Clinical Neuroscience | ELSEVIER SCI LTD | Published : 2013
Abstract
Approximately one-third of people with epilepsy receive insufficient benefit from currently available anticonvulsant medication, and some evidence suggests that this may be due to a lack of effective penetration into brain parenchyma. The current study investigated the ability of biodegradable polymer implants loaded with levetiracetam to ameliorate seizures following implantation above the motor cortex in the tetanus toxin model of temporal lobe epilepsy in rats. The implants led to significantly shorter seizures and a trend towards fewer seizures for up to 1 week. The results of this study indicate that drug-eluting polymer implants represent a promising evolving treatment option for intra..
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Funding Acknowledgements
[ "The authors gratefully acknowledge the donation of Levetiracetam from UCB Pharma, and the sponsorship of the Victorian Government through its Science Technology and Innovation Initiative administered by the Department of Industry, Innovation and Regional Development. The Bionic Ear Institute acknowledges the support it receives from the Victorian Government through its Operational Infrastructure Support Program and the Helen Macpherson Smith Trust. The authors also gratefully acknowledge Dean Freestone and Alan Lai for their assistance in programming the software for review of the EEG data.", "The sources of support include: (i) the Victorian Government's Science Technology and Innovation Initiative administered by the Department of Industry, Innovation and Regional Development; (ii) the Victorian Government through its Operational Infrastructure Support Program and the Helen Macpherson Smith Trust, to the Bionic Ear Institute." ]