Journal article
De novo synthesis of a potent LIMK1 inhibitor
BE Sleebs, IP Street, X Bu, JB Baell
Synthesis | GEORG THIEME VERLAG KG | Published : 2010
Abstract
A potent LIMK1 inhibitor, BMS4, was synthesised in six steps starting from pyrazine-2-carboximidamide, offering a significant improvement over current methods available in the literature. © 2010 Georg Thieme Verlag Stuttgart · New York.
Grants
Funding Acknowledgements
The authors acknowledge the financial support of the Cancer Therapeutics CRC, established and supported under the Australian Government's Cooperative Research Centres Program, Hendrik Falk for assistance with biochemical assays, and Shalong Yang for assistance with synthesis.