Journal article
Lack of evidence from studies of soluble protein fragments that knops blood group polymorphisms in complement receptor-type 1 are driven by malaria
PB Tetteh-Quarcoo, CQ Schmidt, WH Tham, R Hauhart, HDT Mertens, A Rowe, JP Atkinson, AF Cowman, JA Rowe, PN Barlow
Plos One | Published : 2012
Abstract
Complement receptor-type 1 (CR1, CD35) is the immune-adherence receptor, a complement regulator, and an erythroid receptor for Plasmodium falciparum during merozoite invasion and subsequent rosette formation involving parasitized and non-infected erythrocytes. The non-uniform geographical distribution of Knops blood group CR1 alleles Sl1/2 and McCa/b may result from selective pressures exerted by differential exposure to infectious hazards. Here, four variant short recombinant versions of CR1 were produced and analyzed, focusing on complement control protein modules (CCPs) 15-25 of its ectodomain. These eleven modules encompass a region (CCPs 15-17) key to rosetting, opsonin recognition and ..
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Awarded by National Institute of Allergy and Infectious Diseases
Funding Acknowledgements
PBT-Q was funded by the Darwin Trust of Edinburgh; JAR was funded by the Wellcome Trust (Senior Research Fellowship in Basic Biomedical Science grant no. 084226); CQS was funded by WT 081179; and JPA and RH were funded by National Institutes of Health - RO1 AI041592-13. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.