Journal article

Brain and mood changes over 2 years in healthy controls and adults with heart failure and ischaemic heart disease

Osvaldo P Almeida, Griselda J Garrido, Christopher Etherton-Beer, Nicola T Lautenschlager, Leonard Arnolda, Helman Alfonso, Leon Flicker

EUROPEAN JOURNAL OF HEART FAILURE | WILEY | Published : 2013

Abstract

AIMS: Heart failure (HF) has been associated with cognitive dysfunction, a high prevalence of mood disorders, and a relative loss of grey matter in several brain regions. This study aimed to determine if, compared with controls with and without ischaemic heart disease (IHD), adults with HF show evidence of progressive loss of cerebral grey matter, and whether morphological changes are associated with changes in cognition, depression and anxiety symptoms over a follow-up period of 2 years. METHODS AND RESULTS: This was a 24-month longitudinal study of 19 participants with systolic HF, 43 with IHD, and 45 controls. Subjects were older than 45 years and free of cognitive impairment at the start..

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