Journal article

Low-Fouling, Biospecific Films Prepared by the Continuous Assembly of Polymers

Stefanie N Guntari, Edgar HH Wong, Tor K Goh, Rona Chandrawati, Anton Blencowe, Frank Caruso, Greg G Qiao

BIOMACROMOLECULES | AMER CHEMICAL SOC | Published : 2013

Abstract

We report that the continuous assembly of polymers (CAP) approach, mediated by ring-opening metathesis polymerization (ROMP), is a facile and versatile technology to prepare engineered nanocoatings for various biomedical applications. Low-fouling coatings on particles were obtained by the formation of multicompositional, layered films via simple and efficient tandem CAP(ROMP) processes that are analogous to chain extension reactions. In addition, the CAP(ROMP) approach allows for the efficient postfunctionalization of the CAP films with bioactive moieties via cross-metathesis reactions between the surface-immobilized catalysts and symmetrical alkene derivatives. The combined features of the ..

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