Journal article
Targeting antigen to bone marrow stromal cell-2 expressed by conventional and plasmacytoid dendritic cells elicits efficient antigen presentation
JM Moffat, E Segura, G Khoury, I Caminschi, PU Cameron, SR Lewin, JA Villadangos, JD Mintern
European Journal of Immunology | WILEY-BLACKWELL | Published : 2013
Abstract
Bone marrow stromal cell-2 (BST-2) has major roles in viral tethering and modulation of interferon production. Here we investigate BST-2 as a receptor for the delivery of antigen to dendritic cells (DCs). We show that BST-2 is expressed by a panel of mouse and human DC subsets, particularly under inflammatory conditions. The outcome of delivering antigen to BST-2 expressed by steady state and activated plasmacytoid DC (pDC) or conventional CD8+ and CD8- DCs was determined. T-cell responses were measured for both MHC class I (MHCI) and MHC class II (MHCII) antigen presentation pathways in vitro. Delivering antigen via BST-2 was compared with that via receptors DEC205 or Siglec-H. We show that..
View full abstractGrants
Awarded by National Institute of Allergy and Infectious Diseases
Funding Acknowledgements
JDM is an NHMRC (Australia) Career Development Fellow. GK is the recipient of a NHMRC (Australia) Postgraduate Scholarship. This research was funded by a Creative and Novel Ideas in HIV Research Award from the International AIDS Society and National Institute of Health, USA. We acknowledge the helpful advice of Dr. Sandy Clarke at The Statistical Consulting Center, The Department of Mathematics and Statistics, The University of Melbourne.