Journal article
Central nervous system involvement in mantle cell lymphoma: Clinical features, prognostic factors and outcomes from the European mantle cell lymphoma network
CY Cheah, A George, E Giné, A Chiappella, HC Kluin-Nelemans, W Jurczak, K Krawczyk, H Mocikova, P Klener, D Salek, J Walewski, M Szymczyk, L Smolej, RL Auer, DS Ritchie, L Arcaini, ME Williams, M Dreyling, JF Seymour
Annals of Oncology | Published : 2013
Abstract
Background: Central nervous system (CNS) involvement in mantle cell lymphoma (MCL) is uncommon, and the manifestations and natural history are not well described. Patients and methods: We present the data on 57 patients with MCL who developed CNS involvement, from a database of 1396 consecutively treated patients at 14 institutions. Results: The crude incidence of CNS involvement was 4.1%, with 0.9% having CNS involvement at diagnosis. Blastoid histology, B-symptoms, elevated lactate dehydrogenase, Eastern Cooperative Group performance status ≥2 and a high Mantle Cell Lymphoma International Prognostic Index score were enriched in the cohort with CNS involvement, and the presence of ≥1 of the..
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Awarded by Peter MacCallum Cancer Centre
Funding Acknowledgements
This study was made possible by a travel grant from the Department of Haematology, Peter MacCallum Cancer Centre. The Czech Lymphoma Study Group participation was funded by grants IGA-MZ NT/13072-4 and NT13201-4/2012.