Journal article

Gefitinib-induced killing of NSCLC cell lines expressing mutant EGFR requires BIM and can be enhanced by BH3 mimetics

Mark S Cragg, Junya Kuroda, Hamsa Puthalakath, David CS Huang, Andreas Strasser

PLoS Medicine | PUBLIC LIBRARY SCIENCE | Published : 2007

DOI: 10.1371/journal.pmed.0040316

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Awarded by NATIONAL CANCER INSTITUTE

Awarded by NCI NIH HHS

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Keywords

Carcinoma, Non-Small-Cell Lung
Proto-Oncogene Proteins
Medicine, General & Internal
Phosphorylation
Quinazolines
Life Sciences & Biomedicine
Tyrosine Kinase Inhibitor
Humans
Bcl-2-Like Protein 11
Apoptotic Responses
Cell Death
Member
Piperazines
Lung-Cancer
Bcl-2 Family
Membrane Proteins
Mutations
Drug Synergism
Biphenyl Compounds
Identification
Erbb Receptors
Bh3-Only Proteins
Sulfonamides
Science & Technology
General & Internal Medicine
Nitrophenols
Cell Line, Tumor
Apoptosis Regulatory Proteins
Lung Neoplasms
Mutation
Resistance
Gefitinib