Journal article

The Many Roles of FAS Receptor Signaling in the Immune System

Andreas Strasser, Philipp J Jost, Shigekazu Nagata

Immunity | CELL PRESS | Published : 2009


FAS belongs to the subgroup of the tumor necrosis factor receptor (TNF-R) family that contains an intracellular "death domain" and triggers apoptosis. Its physiological ligand FASL is a member of the TNF cytokine family. Studies with mutant mice and cells from human patients have shown that FAS plays critical roles in the immune system, including the killing of pathogen-infected cells and the death of obsolete and potentially dangerous lymphocytes. Fas thereby functions as a guardian against autoimmunity and tumor development. FAS triggers apoptosis through FADD-mediated recruitment and activation of caspase-8. In certain cells such as hepatocytes, albeit not lymphocytes, FAS-induced apoptos..

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University of Melbourne Researchers


Awarded by National Health and Medical Research Council

Awarded by Leukemia and Lymphoma Society

Awarded by National Cancer Institute


Funding Acknowledgements

Work in our laboratories was supported by fellowships and grants from the National Health and Medical Research Council (Australia; #257502, #461263, and #356214); the Leukemia and Lymphoma Society (New York; SCOR grant #7015); the National Cancer Institute (NIH, US; CA 80188 and CA 43540); the Mildred Scheel-Stiftung/Deutsche Krebshilfe; the Ministry of Education, Science, Sports, and Culture in Japan (Specially Promoted Research); and the Japan Science and Technology Agency (SORST).