Journal article

Gene dosage-limiting role of Aire in thymic expression, clonal deletion, and organ-specific autoimmunity

A Liston, DHD Gray, S Lesage, AL Fletcher, J Wilson, KE Webster, HS Scott, RL Boyd, L Peltonen, CC Goodnow

JOURNAL OF EXPERIMENTAL MEDICINE | ROCKEFELLER UNIV PRESS | Published : 2004

Abstract

Inactivation of the autoimmune regulator (Aire) gene causes a rare recessive disorder, autoimmune polyendocrine syndrome 1 (APS1), but it is not known if Aire-dependent tolerance mechanisms are susceptible to the quantitative genetic changes thought to underlie more common autoimmune diseases. In mice with a targeted mutation, complete loss of Aire abolished expression of an insulin promoter transgene in thymic epithelium, but had no effect in pancreatic islets or the testes. Loss of one copy of Aire diminished thymic expression of the endogenous insulin gene and the transgene, resulting in a 300% increase in islet-reactive CD4 T cells escaping thymic deletion in T cell receptor transgenic m..

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University of Melbourne Researchers