Journal article

Genetic and environmental factors determining clinical outcomes and cost of warfarin therapy: a prospective study

Andrea L Jorgensen, Sameh Al-Zubiedi, Jieying Eunice Zhang, Andrew Keniry, Anita Hanson, Dyfrig A Hughes, Diane van Eker, Lisa Stevens, Karen Hawkins, Cheng H Toh, Farhad Kamali, Ann K Daly, David Fitzmaurice, Alison Coffey, Paula R Williamson, Brian Kevin Park, Panos Deloukas, Munir Pirmohamed


University of Melbourne Researchers


Funding Acknowledgements

The authors acknowledge the UK Department of Health for funding the study. The support of the Wellcome Trust is also acknowledged. The authors thank all the clinicians, nurses and pharmacists who helped us in recruiting patients, and the patients for taking part in the study, and the Roald Dahl Anticoagulant clinic in the Royal Liverpool Hospital. The authors also acknowledge the contribution of Dr Vanessa Martlew (Royal Liverpool Hospital) and Dr Dasgupta (University Hospital Aintree) for patient recruitment. The authors thank Susanna Dodd and Fabio Miyajima, University of Liverpool, for their assistance with the analysis of the cost data.The conception and design of the study was undertaken by M.P., D.A.H., A.C., EK., A.D., D.E, P.R.W, B.K.P. and RD. A.L.J. was responsible for monitoring of data (also done by P.R.W), statistical analyses of associations with response to warfarin, and wrote the first draft of the manuscript. J.E.Z. undertook all laboratory analyses of clotting factors and preparation of laboratory samples, while A.K. undertook genotyping, supervised by PD. A.H., D.E., K.H. and L.S. recruited the patients, designed the C.R.E and validated the patient data, while C.H.T facilitated patient identification and quality assurance of the coagulation based laboratory tests. A.C. supervised the DNA extraction. SAX and DA.H. undertook the cost analysis. M.P. is the principal investigator, conceived the design of the study, coordinated the study, was involved in data monitoring and assessment of patients, and co-wrote first draft. All authors were involved in reviewing the manuscript and approved the final version. M.P. acts as guarantor for the study.