Repeated replication and a prospective meta-analysis of the association between chromosome 9p21.3 and coronary artery disease

H Schunkert; A Götz; P Braund; R McGinnis; DA Tregouet; M Mangino; P Linsel-Nitschke; F Cambien; C Hengstenberg; K Stark; S Blankenberg; L Tiret; P Ducimetiere; A Keniry; MJR Ghori; S Schreiber; NE El Mokhtari; AS Hall; RJ Dixon; AH Goodall; H Liptau; H Pollard; DF Schwarz; LA Hothorn; HE Wichmann; IR König; M Fischer; C Meisinger; W Ouwehand; P Deloukas; JR Thompson; J Erdmann; A Ziegler; NJ Samani

Journal article

Repeated replication and a prospective meta-analysis of the association between chromosome 9p21.3 and coronary artery disease

H Schunkert, A Götz, P Braund, R McGinnis, DA Tregouet, M Mangino, P Linsel-Nitschke, F Cambien, C Hengstenberg, K Stark, S Blankenberg, L Tiret, P Ducimetiere, A Keniry, MJR Ghori, S Schreiber, NE El Mokhtari, AS Hall, RJ Dixon, AH Goodall Show all

Circulation | Published : 2008

DOI: 10.1161/CIRCULATIONAHA.107.730614

Abstract

BACKGROUND - Recently, genome-wide association studies identified variants on chromosome 9p21.3 as affecting the risk of coronary artery disease (CAD). We investigated the association of this locus with CAD in 7 case-control studies and undertook a meta-analysis. METHODS AND RESULTS - A single-nucleotide polymorphism (SNP), rs1333049, representing the 9p21.3 locus, was genotyped in 7 case-control studies involving a total of 4645 patients with myocardial infarction or CAD and 5177 controls. The mode of inheritance was determined. In addition, in 5 of the 7 studies, we genotyped 3 additional SNPs to assess a risk-associated haplotype (ACAC). Finally, a meta-analysis of the present data and pr..

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