Journal article

The H19 lincRNA is a developmental reservoir of miR-675 that suppresses growth and lgf1r

Andrew Keniry, David Oxley, Paul Monnier, Michael Kyba, Luisa Dandolo, Guillaume Smits, Wolf Reik


University of Melbourne Researchers


Awarded by NIH/NHLBI

Awarded by Biotechnology and Biological Sciences Research Council

Awarded by Medical Research Council

Funding Acknowledgements

We thank D. L. Kontoyiannis (Alexander Fleming Biomedical Sciences Research Center, Greece) for supplying HuR<SUP>-/-</SUP> MEF cells. We also thank H. Jammes and A. Gabory for assisting with collection of the H19<SUP>Delta 3</SUP> phenotypic data, J. Webster for preparing samples for mass spectrometry and W. Dean for tissue collections. The authors would also like to thank K. Tabbada, A. Segonds-Pichon and S. Andrews for RNA sequencing, statistical and bioinformatic assistance, respectively. We thank M. lacovino for creating the A2lox-cre ES cell line. We would also like to thank T. Hore, C. Krueger and J. Houseley for critical reading of the manuscript and all members of the laboratories of W. Reik, M. Hemberger, E. Vigorito and). Houseley for helpful discussions. This work was supported by BBSRC, the Wellcome Trust, MRC, EU NoE EpiGeneSys, EU BLUEPRINT, NIH/NHLBI (U01HL100407) and the Cambridge Commonwealth Trust.