Journal article

Loss of c-Cbl RING finger function results in high-intensity TCR signaling and thymic deletion

CBF Thien, FD Blystad, YF Zhan, AM Lew, V Voigt, CE Andoniou, WY Langdon

EMBO J. | WILEY | Published : 2005

DOI: 10.1038/sj.emboj.7600841

University of Melbourne Researchers

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Keywords

Proto-Oncogene Proteins C-Cbl
Apoptosis
Thymus
Cd5 Antigens
Mechanisms
Extracellular Signal-Regulated Map Kinases
Life Sciences & Biomedicine
Receptors, Antigen, T-Cell
Cell Biology
Antigens, Cd
Signal Transduction
Thymus Gland
Tyrosine Phosphorylation
Down-Regulation
Mice, Transgenic
Lymphocyte Specific Protein Tyrosine Kinase P56(lck)
Phosphatidylinositol 3-Kinases
Animals
Biochemistry & Molecular Biology
Activation
Amino Acid Substitution
Akt
Mutation
Science & Technology
Cd3 Complex
Lectins, C-Type
Mice
Family Proteins
Expression
Negative Selection
Antigens, Cd3
Antigens, Cd5
Fyn
Antigens, Differentiation, T-Lymphocyte
Cd3
Cbl
Protein Structure, Tertiary
Thymocytes
Zap-70