Journal article

EGL-1 BH3 mutants reveal the importance of protein levels and target affinity for cell-killing potency

EF Lee, L Chen, H Yang, PM Colman, DCS Huang, WD Fairlie

Cell Death Differ. | NATURE PUBLISHING GROUP | Published : 2008


Awarded by Australian NHMRC

Awarded by US NCI

Awarded by Leukemia and Lymphoma Society

Awarded by Cancer Council of Victoria


Funding Acknowledgements

We thank H Ierino, K Knezevic and M Evangelista for technical assistance; R Anderson, S Korsmeyer, N Motoyama, C Thompson, and W Welch for reagents and A Strasser, P Bouillet, P Kelly and M van Delft for the mcl-f<SUP>-/-</SUP> cells. This work was supported by grants from the Australian NHMRC (Program Grant 257502), US NCI (CA80188), Leukemia and Lymphoma Society (Specialized Center of Research 7015-02), the Cancer Council of Victoria (Project 461239), fellowships and scholarships from the NHMRC (DCSH, WDF, PMC) and the Cancer Council of Victoria (PMC - Fraser Fellowship, EFL).