Journal article

EGL-1 BH3 mutants reveal the importance of protein levels and target affinity for cell-killing potency

EF Lee, L Chen, H Yang, PM Colman, DCS Huang, WD Fairlie

Cell Death Differ. | NATURE PUBLISHING GROUP | Published : 2008

Grants

Awarded by Australian NHMRC


Awarded by US NCI


Awarded by Leukemia and Lymphoma Society


Awarded by Cancer Council of Victoria


Awarded by NATIONAL CANCER INSTITUTE


Funding Acknowledgements

We thank H Ierino, K Knezevic and M Evangelista for technical assistance; R Anderson, S Korsmeyer, N Motoyama, C Thompson, and W Welch for reagents and A Strasser, P Bouillet, P Kelly and M van Delft for the mcl-f<SUP>-/-</SUP> cells. This work was supported by grants from the Australian NHMRC (Program Grant 257502), US NCI (CA80188), Leukemia and Lymphoma Society (Specialized Center of Research 7015-02), the Cancer Council of Victoria (Project 461239), fellowships and scholarships from the NHMRC (DCSH, WDF, PMC) and the Cancer Council of Victoria (PMC - Fraser Fellowship, EFL).