Journal article
Blimp1 is limiting for transformation in a mouse plasmacytoma model
K D'Costa, D Emslie, D Metcalf, GK Smyth, A Karnowski, A Kallies, SL Nutt, LM Corcoran
Blood | AMER SOC HEMATOLOGY | Published : 2009
Abstract
Multiple myeloma (MM) and plasmacytomas are cancers of antibody-secreting cells (ASCs). PRDM1/BLIMP1 is an essential regulator of ASC development. Histologic evidence shows that 100% of MM expresses PRDM1/BLIMP1, indicating that PRDM1/BLIMP1 is important for the development or persistence of MM. In contrast, some diffuse large B-cell lymphomas (DLBCLs) lose PRDM1 expression, suggesting that PRDM1 may act as a tumor suppressor in DLBCL. Thus, the role of PRDM1/BLIMP1 in transformation of mature B cells is unclear. We have used a plasmacytoma-prone transgenic mouse model to study the effect of Blimp1 loss on plasmacytoma prevalence, latency, and phenotype. Two possible outcomes could be envisa..
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Awarded by Australian National Health and Medical Research Council (NHMRC)
Funding Acknowledgements
This work was supported by the Australian National Health and Medical Research Council (NHMRC; IRIISS grant 361646), an NHMRC Program grant ( 356202), and a Victorian State Government OIS grant.