Journal article

Early appearance of germinal center-derived memory B cells and plasma cells in blood after primary immunization

EJ Blink, A Light, A Kallies, SL Nutt, PD Hodgkin, DM Tarlinton

Journal of Experimental Medicine | ROCKEFELLER UNIV PRESS | Published : 2005


Immunization with a T cell-dependent antigen elicits production of specific memory B cells and antibody-secreting cells (ASCs). The kinetic and developmental relationships between these populations and the phenotypic forms they and their precursors may take remain unclear. Therefore, we examined the early stages of a primary immune response, focusing on the appearance of antigen-specific B cells in blood. Within 1 wk, antigen-specific B cells appear in the blood with either a memory phenotype or as immunoglobulin (Ig)G1 ASCs expressing blimp-1. The memory cells have mutated V(H) genes; respond to the chemokine CXCL13 but not CXCL12, suggesting recirculation to secondary lymphoid organs; unif..

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