Journal article

Remarkable in vitro bactericidal activity of bismuth(III) sulfonates against Helicobacter pylori

Philip C Andrews, Madleen Busse, Glen B Deacon, Richard L Ferrero, Peter C Junk, Jonathan G MacLellan, Amelia Vom



Four new tris-substituted bismuth(III) sulfonates of general formula [Bi(O(3)SR)(3)] (R = phenyl 1, p-tolyl 2, 2,4,6-mesityl 3 and S-(+)-10-camphoryl 4) have been synthesised and characterised. Their synthesis by solvent-free (SF) and solvent-mediated (SM) methods has been explored and their activity against Helicobacter pylori has been investigated. The compounds 1-4 display a remarkable in vitro activity against three laboratory strains of H. pylori (B128, 26,695 and 251) with minimum inhibitory concentration (MIC) values as low as 0.049 μg mL(-1) for the strains B128 and 26,695, and 0.781 μg mL(-1) for the clinical isolate 251. This places most MIC values in the nano-molar region and demo..

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University of Melbourne Researchers


Funding Acknowledgements

We thank the Australian Research Council, National Health and Medical Research Council (RLF), Monash University, Monash University Postgraduate Publication Award Scheme (MB), Bayer Schering and Victorian Government's Operational Infrastructure Support Program (MIMR) for financial support. We are thankful for the crystallographic advice given by Dr Craig M. Forsyth, and to Katharina Scholze (Universitat Leipzig) for some of her early efforts on this project.