Journal article

Omega-3 Fatty Acid Supplementation in Adolescents With Borderline Personality Disorder and Ultra-High Risk Criteria for Psychosis: A Post Hoc Subgroup Analysis of a Double-Blind, Randomized Controlled Trial

G Paul Amminger, Andrew M Chanen, Susanne Ohmann, Claudia M Klier, Nilufar Mossaheb, Andreas Bechdolf, Barnaby Nelson, Andrew Thompson, Patrick D McGorry, Alison R Yung, Miriam R Schaefer



OBJECTIVE: To investigate whether long-chain omega-3 (n-3) polyunsaturated fatty acids (PUFAs) improve functioning and psychiatric symptoms in young people with borderline personality disorder (BPD) who also meet ultra-high risk criteria for psychosis. METHODS: We conducted a post hoc subgroup analysis of a double-blind, randomized controlled trial. Fifteen adolescents with BPD (mean age 16.2 years, [SD 2.1]) were randomized to either 1.2 g/day n-3 PUFAs or placebo. The intervention period was 12 weeks. Study measures included the Positive and Negative Syndrome Scale, the Montgomery-Åsberg Depression Rating Scale, and the Global Assessment of Functioning. Side effects were documented with th..

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Awarded by Stanley Medical Research Institute

Awarded by National Health and Medical Research Council (NHMRC), Australia

Awarded by NHMRC Career Development Fellowship

Funding Acknowledgements

Our study was supported by a grant from the Stanley Medical Research Institute (03T-315). Dr Amminger is supported by a grant from the National Health and Medical Research Council (NHMRC), Australia (566529). Dr Nelson is supported by an NHMRC Career Development Fellowship (1027532). Konstantinos Papageorgiou assisted with research assessments. Magdalena Holub, Ingrid Holzer, Margit Kornsteiner, and Jessica Slavik assisted with the erythrocyte fatty acid analysis. Dr Michael Kaess provided helpful comments on this manuscript. The Orygen Youth Health Research Centre is supported by an unrestricted grant from the Colonial Foundation, Melbourne, Australia. Dr Amminger, Dr Chanen, and Dr Schafer participated in the design and conception of the study, the data analysis, and the interpretation of the data. Dr Amminger, Dr Ohmann, Dr Klier, and Dr Schafer were involved as clinicians and (or) research assessors. All authors contributed to the writing of the paper and have seen and approved the final version.