Dietary Intake of B Vitamins and Methionine and Colorectal Cancer Risk
Julie K Bassett, Gianluca Severi, Allison M Hodge, Laura Baglietto, John L Hopper, Dallas R English, Graham G Giles
NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL | ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD | Published : 2013
B vitamins are involved in 1-carbon metabolism, which is necessary for DNA replication, DNA repair, and regulation of gene expression. Recent studies suggest inverse associations between folate and vitamin B6 intakes and colorectal cancer risk but associations with other B vitamins and methionine have not been widely studied. After following 14,645 men and 22,467 women for 15 yr on average, we ascertained 910 incident colorectal cancers. Dietary intakes were estimated using a 121-item food frequency questionnaire. Hazard ratios (HRs) and 95% confidence intervals were estimated using Cox regression. We found some evidence of a U-shaped relationship between colon cancer risk and vitamin B6 and..View full abstract
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Awarded by NHMRC
Cohort recruitment was funded by VicHealth and The Cancer Council Victoria. This work was supported by infrastructure from the Cancer Council Victoria and grants from the NHMRC (209057, 251533, 520316). This study was made possible by the contribution of many people, including the original investigators and the diligent team who recruited the participants and who continue working on follow-up. We would also like to express our gratitude to the many thousands of Melbourne residents who continue to participate in the study.