Mechanisms That Determine the Internal Environment of the Developing Brain: A Transcriptomic, Functional and Ultrastructural Approach
Shane A Liddelow, Katarzyna M Dziegielewska, C Joakim Ek, Mark D Habgood, Hannelore Bauer, Hans-Christian Bauer, Helen Lindsay, Matthew J Wakefield, Nathalie Strazielle, Ingrid Kratzer, Kjeld Mollgard, Jean-Francois Ghersi-Egea, Norman R Saunders
PLOS ONE | PUBLIC LIBRARY SCIENCE | Published : 2013
We provide comprehensive identification of embryonic (E15) and adult rat lateral ventricular choroid plexus transcriptome, with focus on junction-associated proteins, ionic influx transporters and channels. Additionally, these data are related to new structural and previously published permeability studies. Results reveal that most genes associated with intercellular junctions are expressed at similar levels at both ages. In total, 32 molecules known to be associated with brain barrier interfaces were identified. Nine claudins showed unaltered expression, while two claudins (6 and 8) were expressed at higher levels in the embryo. Expression levels for most cytoplasmic/regulatory adaptors (10..View full abstract
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Awarded by National Health and Medical Research Council (Australia)
Awarded by European Union Seventh Framework Program (FP7) Neurobid consortium
SAL, KMD and NRS are supported by the National Health and Medical Research Council (Australia) - Grant No. 567205. SAL, KMD, NRS, CJE, HB, H-CB, NS, J-FG-E are supported by the European Union Seventh Framework Program (FP7) Neurobid consortium - Agreement No. HEALTH-F2-2009-241778, KM was an advisor to the consortium. SAL was supported as a Neurological Fellow by the by the American-Australian Association. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.