Journal article
Combined effects of child and adult elevated blood pressure on subclinical atherosclerosis: The international childhood cardiovascular cohort consortium
J Juhola, CG Magnussen, GS Berenson, A Venn, TL Burns, MA Sabin, SR Srinivasan, SR Daniels, PH Davis, W Chen, M Kähönen, L Taittonen, E Urbina, JSA Viikari, T Dwyer, OT Raitakari, M Juonala
Circulation | LIPPINCOTT WILLIAMS & WILKINS | Published : 2013
Abstract
BACKGROUND - : Elevated blood pressure (BP) levels in childhood have been associated with subsequent atherosclerosis. However, it is uncertain whether this risk is attenuated in individuals who acquire normal BP by adulthood. The present study examined the effect of child and adult BP levels on carotid artery intima-media thickness (IMT) in adulthood. METHODS AND RESULTS - : The cohort consisted of 4210 participants from 4 prospective studies (mean follow-up, 23 years). Childhood elevated BP was defined according to the tables from the National High Blood Pressure Education Program. In adulthood, BP was classified as elevated for individuals with systolic BP ≥120 mm Hg, diastolic BP ≥80 mm H..
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Awarded by National Heart, Lung, and Blood Institute
Funding Acknowledgements
These analyses were supported by funding from the individual studies. The Muscatine Study was supported by grants from the National Heart, Lung, and Blood Institute (HL-14230 and HL-54730), and the General Clinical Research Centers Program (RR-00059) of the National Institutes of Health. The Bogalusa Heart Study is supported by grants AG-16592 from the National Institute on Aging and ES-021724 from National Institute of Environmental Health Science. The Cardiovascular Risk in Young Finns Study was supported by grants from the Academy of Finland (121584, 126925, 124282, 129378), the Social Insurance Institution of Finland, the Turku University Foundation, Special Federal Grants for University Hospitals, the JuhoVainio Foundation, PaavoNurmi Foundation, the Finnish Foundation of Cardiovascular Research, Orion-Farmos Research Foundation, the Ida Montin Foundation, and the Finnish Cultural Foundation. The Childhood Determinants of Adult Health Study was supported at baseline by the Commonwealth Departments of Sport, Recreation and Tourism, and Health; the National Heart Foundation; and the Commonwealth Schools Commission and at follow-up by the National Health and Medical Research Council, the Heart Foundation, the Tasmanian Community Fund, and Veolia Environmental Services. Authors from the Murdoch Children's Research Institute are supported by the Victorian Government Operational Infrastructure Support Program. Drs Magnussen, Venn, and Savin are supported by fellowships from the National Health & Medical Research Council (Australia).