Journal article
Serum inflammatory markers and preeclampsia in type 1 diabetes: A prospective study
M Du, A Basu, D Fu, M Wu, M Centola, AJ Jenkins, KF Hanssen, SK Garg, SM Hammad, JA Scardo, CE Aston, TJ Lyons
Diabetes Care | Published : 2013
DOI: 10.2337/dc12-1934
Open access
Abstract
OBJECTIVE-Inflammation and endothelial dysfunction have been associated with the immunobiology of preeclampsia (PE), a significant cause of adverse pregnancy outcomes. The prevalence of PE is elevated several fold in the presence of maternal type 1 diabetes mellitus (T1DM). Although cross-sectional studies of pregnancies among women without diabetes have shown altered inflammatory markers in the presence of PE, longitudinal studies of diabetic women are lacking. In maternal serum samples, we examined the temporal associations of markers of inflammation with the subsequent development of PE in women with T1DM. RESEARCH DESIGN ANDMETHODS-We conducted longitudinal analyses of serum C-reactive p..
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Awarded by National Center for Research Resources
Funding Acknowledgements
T.J.L. received support through research grants from the Juvenile Diabetes Research Foundation (JDRF 1-2001-844) and Novo Nordisk. This study also was funded by National Institutes of Health (National Center for Research Resources) grants M01-RR-1070 and M01 RR-14467 to the General Clinical Research Centers at Medical University of South Carolina and University of Oklahoma Health Sciences Center, respectively. Support from Novo Nordisk enabled the participation of the Barbara Davis Diabetes Center for Childhood Diabetes at the University of Colorado. No other potential conflicts of interest relevant to this article were reported.