Genome-wide association study identifies multiple risk loci for chronic lymphocytic leukemia

SI Berndt; CF Skibola; V Joseph; NJ Camp; A Nieters; Z Wang; W Cozen; A Monnereau; SS Wang; RS Kelly; Q Lan; LR Teras; N Chatterjee; CC Chung; M Yeager; AR Brooks-Wilson; P Hartge; MP Purdue; BM Birmann; BK Armstrong; P Cocco; Y Zhang; G Severi; A Zeleniuch-Jacquotte; C Lawrence; L Burdette; J Yuenger; A Hutchinson; KB Jacobs; TG Call; TD Shanafelt; AJ Novak; NE Kay; M Liebow; AH Wang; KE Smedby; HO Adami; M Melbye; B Glimelius; ET Chang; M Glenn; K Curtin; LA Cannon-Albright; B Jones; WR Diver; BK Link; GJ Weiner; L Conde; PM Bracci; J Riby; EA Holly; MT Smith; RD Jackson; LF Tinker; Y Benavente; N Becker; P Boffetta; P Brennan; L Foretova; M Maynadie; J McKay; A Staines; KG Rabe; SJ Achenbach; CM Vachon; LR Goldin; SS Strom; MC Lanasa; LG Spector; JF Leis; JM Cunningham; JB Weinberg; VA Morrison; NE Caporaso; AD Norman; MS Linet; AJ De Roos; LM Morton; RK Severson; E Riboli; P Vineis; R Kaaks; D Trichopoulos; G Masala; E Weiderpass; MD Chirlaque; RCH Vermeulen; RC Travis; GG Giles; D Albanes; J Virtamo; S Weinstein; J Clavel; T Zheng; TR Holford; K Offit; A Zelenetz; RJ Klein; JJ Spinelli; KA Bertrand

Journal article

Genome-wide association study identifies multiple risk loci for chronic lymphocytic leukemia

SI Berndt, CF Skibola, V Joseph, NJ Camp, A Nieters, Z Wang, W Cozen, A Monnereau, SS Wang, RS Kelly, Q Lan, LR Teras, N Chatterjee, CC Chung, M Yeager, AR Brooks-Wilson, P Hartge, MP Purdue, BM Birmann, BK Armstrong Show all

Nature Genetics | NATURE PUBLISHING GROUP | Published : 2013

DOI: 10.1038/ng.2652

Abstract

Genome-wide association studies (GWAS) have previously identified 13 loci associated with risk of chronic lymphocytic leukemia or small lymphocytic lymphoma (CLL). To identify additional CLL susceptibility loci, we conducted the largest meta-analysis for CLL thus far, including four GWAS with a total of 3,100 individuals with CLL (cases) and 7,667 controls. In the meta-analysis, we identified ten independent associated SNPs in nine new loci at 10q23.31 (ACTA2 or FAS (ACTA2/FAS), P = 1.22 × 10-14), 18q21.33 (BCL2, P = 7.76 × 10-11), 11p15.5 (C11orf21, P = 2.15 × 10 -10), 4q25 (LEF1, P = 4.24 × 10-10), 2q33.1 (CASP10 or CASP8 (CASP10/CASP8), P = 2.50 × 10-9), 9p21.3 (CDKN2B-AS1, P = 1.27 × 10-..

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University of Melbourne Researchers

Graham Giles Author

Grants

Awarded by National Cancer Institute

Funding Acknowledgements

We thank C. Allmer, E. Angelucci, A. Bigelow, I. Brock, K. Butterbach, A. Chabrier, D. Chan-Lam, J.M. Conners, D. Connley, M. Cornelis, K. Corsano, C. Dalley, D. Cox, H. Cramp, R. Cutting, H. Dykes, L. Ershler, A. Gabbas, R.P. Gallagher, R.D. Gascoyne, P. Hui, L. Irish, L. Jacobus, S. Kaul, J. Lunde, M. McAdams, R. Montalvan, M. Rais, T. Rattle, L. Rigacci, K. Snyder, G. Specchia, M. Stagner, P. Taylor, G. Thomas, C. Tornow, G. Wood, M. Yang and M. Zucca for their assistance. The overall GWAS project was supported by the intramural program of the Division of Cancer Epidemiology and Genetics, NCI, US National Institutes of Health. A full list of acknowledgments is provided in the Supplementary Note.