Journal article
Transcriptional programming of the dendritic cell network
GT Belz, SL Nutt
Nature Reviews Immunology | Published : 2012
DOI: 10.1038/nri3149
Abstract
Specialized subsets of dendritic cells (DCs) provide a crucial link between the innate and adaptive immune responses. The genetic programme that coordinates these distinct DC subsets is controlled by both cytokines and transcription factors. The initial steps in DC specification occur in the bone marrow and result in the generation of precursors committed to either the plasmacytoid or conventional DC pathways. DCs undergo further differentiation and lineage diversification in peripheral organs in response to local environmental cues. In this Review, we discuss new evidence regarding the coordination of the specification and commitment of precursor cells to different DC subsets and highlight ..
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Funding Acknowledgements
The authors thank R. Allan, A. Kallies, M. Chopin and M. Pellegrini for helpful discussions and critical reading of the manuscript. This work is supported by the National Health and Medical Research Council (NHMRC) of Australia and the Wellcome Trust. G.T.B. is supported by a Sylvia and Charles Viertel Foundation Fellowship and S.L.N. is supported by an Australian Research Council Future Fellowship. This work was made possible by Victorian State Government Operational Infrastructure Support and the Australian Government NHMRC Independent Research Institute Infrastructure Support Scheme.