Journal article

CCR7 signals are essential for cortex-medulla migration of developing thymocytes

T Ueno, F Saito, DHD Gray, S Kuse, K Hieshima, H Nakano, T Kakiuchi, M Lipp, RL Boyd, Y Takahama

Journal of Experimental Medicine | ROCKEFELLER UNIV PRESS | Published : 2004


Upon TCR-mediated positive selection, developing thymocytes relocate within the thymus from the cortex to the medulla for further differentiation and selection. However, it is unknown how this cortex-medulla migration of thymocytes is controlled and how it controls T cell development. Here we show that in mice deficient for CCR7 or its ligands mature single-positive thymocytes are arrested in the cortex and do not accumulate in the medulla. These mutant mice are defective in forming the medullary region of the thymus. Thymic export of T cells in these mice is compromised during the neonatal period but not in adulthood. Thymocytes in these mice show no defects in maturation, survival, and neg..

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University of Melbourne Researchers