Journal article

CCR7 signals are essential for cortex-medulla migration of developing thymocytes

T Ueno, F Saito, DHD Gray, S Kuse, K Hieshima, H Nakano, T Kakiuchi, M Lipp, RL Boyd, Y Takahama

Journal of Experimental Medicine | ROCKEFELLER UNIV PRESS | Published : 2004

Abstract

Upon TCR-mediated positive selection, developing thymocytes relocate within the thymus from the cortex to the medulla for further differentiation and selection. However, it is unknown how this cortex-medulla migration of thymocytes is controlled and how it controls T cell development. Here we show that in mice deficient for CCR7 or its ligands mature single-positive thymocytes are arrested in the cortex and do not accumulate in the medulla. These mutant mice are defective in forming the medullary region of the thymus. Thymic export of T cells in these mice is compromised during the neonatal period but not in adulthood. Thymocytes in these mice show no defects in maturation, survival, and neg..

View full abstract

University of Melbourne Researchers