Journal article
The BH3-mimetic ABT-737 induces mast cell apoptosis in vitro and in vivo: Potential for therapeutics
M Karlberg, M Ekoff, DCS Huang, P Mustonen, IT Harvima, G Nilsson
Journal of Immunology | Published : 2010
Abstract
Mast cells and their mediators are implicated in the pathogenesis of many different diseases. One possible therapeutic intervention in mast cell-associated diseases can be to reduce the number of tissue mast cells by inducing mast cell apoptosis. In this study, we demonstrate that mast cells exhibit a high sensitivity to ABT-737, a BH3-only mimetic molecule that induces apoptosis through high-affinity binding to the prosurvival proteins, Bcl-2, Bcl-XL, and Bcl-w. Primary mast cells as well as mast cell lines tested succumbed to apoptosis in response to the inhibitor at varying but seemingly low concentrations compared with other leukocytes investigated. I.p. injections of ABT-737 in mice res..
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Awarded by National Cancer Institute
Funding Acknowledgements
This work was supported by the Swedish Cancer Society, the Swedish Research Council-Medicine; the Centre for Allergy Research at Karolinska Institutet; King Gustaf V's 80-years Foundation; the Ollie and Elof Ericssons Foundation; Hans von Kant-zow's Foundation; the Ellen, Walter and Lennart Hesselmans Foundation; the Kuopio University Hospital; the Australian National Health and Medical Research Council (Program Grant 461221); the National Institutes of Health (CA80188 and CA43540); the Leukemia and Lymphoma Society (Specialized Center of Research Grant 7413); and the Victorian State Government (Operational Infrastructure Support grant).