Journal article

Associations between Weight in Early Adulthood, Change in Weight, and Breast Cancer Risk in Postmenopausal Women

Kavitha Krishnan, Julie K Bassett, Robert J MacInnis, Dallas R English, John L Hopper, Catriona McLean, Graham G Giles, Laura Baglietto



BACKGROUND: Adult weight is positively associated with postmenopausal breast cancer but few studies have investigated whether there are associations with weight and body mass index (BMI) in early adulthood, or subsequent weight change. METHODS: A total of 14,441 postmenopausal women from the Melbourne Collaborative Cohort Study (MCCS) were followed for 16.5 years (mean) and 668 incident breast cancers were identified. Hazard ratios (HRs) were estimated using Cox regression. RESULTS: Weight and BMI at 18 to 21 years were not associated with risk of any type of breast cancer and there was no variation by age. Women with the greatest increase in weight and BMI had higher risk at older ages [HR ..

View full abstract


Awarded by National Health and Medical Research Council

Awarded by National Breast Cancer Foundation

Funding Acknowledgements

This study was made possible by the contribution of many people, including the original investigators, the Program Manager, and the diligent team who recruited the participants and who continue working on follow-up. The authors also thank many thousands of Melbourne residents who continue to participate in the study. Cohort recruitment was funded by VicHealth and The Cancer Council Victoria. This study was funded by grants from the National Health and Medical Research Council (251533, 209057, 504711) and The National Breast Cancer Foundation and was further supported by infrastructure provided by The Cancer Council Victoria.