Journal article
High FDG activity in focal fat necrosis: A pitfall in interpretation of posttreatment PET/CT in patients with non-Hodgkin lymphoma
R Kashyap, E Lau, A George, JF Seymour, S Lade, RJ Hicks, MS Hofman
European Journal of Nuclear Medicine and Molecular Imaging | Published : 2013
Abstract
Purpose: PET/CT has a major role in lymphoma imaging, but glycolytic activity in inflammatory processes can reduce specificity. In this study we evaluated restaging PET/CT findings in patients with non-Hodgkin lymphoma (NHL) and fat necrosis. Methods: We identified 16 patients from 8,819 restaging FDG PET/CT scans with suspicion of or biopsy-proven fat necrosis on PET/CT. Results: All patients had NHL and demonstrated focal FDG-avid nodular change on CT with density higher than that of fat but lower than that of soft tissue. Histological confirmation was obtained in eight patients, with high GLUT-1 staining between necrotic tissue and organizing fat necrosis evident. Uptake resolved in four ..
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Funding Acknowledgements
We would like to thank Dr. M. Dickinson, Professor M. Prince and Associate Professor D. Ritchie for contributing cases. Dr. R. Kashyap was supported by Endeavour Awards, a venture of Austraining International in partnership with the Government of Australia.