Journal article

Growing Vascularized Heart Tissue From Stem Cells

Shiang Y Lim, Damian Hernandez, Gregory J Dusting

JOURNAL OF CARDIOVASCULAR PHARMACOLOGY | LIPPINCOTT WILLIAMS & WILKINS | Published : 2013

Abstract

The promise of stem cells to repair the heart after damage or heart attack has not been realized because most such cells are lost after transplantation. A new approach is to grow substantial viable pieces of cardiac tissue from human stem cells by cardiac tissue engineering. Such constructs must be fully vascularized and perfused to ensure the viability of clinically relevant volumes of tissue. This requires careful choice of cells, culture conditions, a biomaterial to act as scaffold, and crucial strategies for vascularization. Autologous stem cells with high plasticity, which would avoid the need for antirejection therapies after transplantation, are an attractive source of both cardiomyoc..

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Grants

Funding Acknowledgements

Supported by National Heart Foundation and National Health and Medical Research Council of Australia for project grant, Principal Research Fellow to G. J. Dusting, and Melbourne International Research Scholarship to D. Hernandez. Support is also provided by the JR and JO Wicking Trust and the Victorian State Government's Department of Innovation, Industry, and Regional Development's Operational Infrastructure Support Program.