Long-term Follow-up of a Group at Ultra High Risk ("Prodromal") for Psychosis The PACE 400 Study

Barnaby Nelson; Hok Pan Yuen; Stephen J Wood; Ashleigh Lin; Daniela Spiliotacopoulos; Annie Bruxner; Christina Broussard; Magenta Simmons; Debra L Foley; Warrick J Brewer; Shona M Francey; G Paul Amminger; Andrew Thompson; Patrick D McGorry; Alison R Yung

Journal article

Long-term Follow-up of a Group at Ultra High Risk ("Prodromal") for Psychosis The PACE 400 Study

Barnaby Nelson, Hok Pan Yuen, Stephen J Wood, Ashleigh Lin, Daniela Spiliotacopoulos, Annie Bruxner, Christina Broussard, Magenta Simmons, Debra L Foley, Warrick J Brewer, Shona M Francey, G Paul Amminger, Andrew Thompson, Patrick D McGorry, Alison R Yung

JAMA PSYCHIATRY | AMER MEDICAL ASSOC | Published : 2013

DOI: 10.1001/jamapsychiatry.2013.1270

Abstract

IMPORTANCE: The ultra high-risk (UHR) criteria were introduced to prospectively identify patients at high risk of psychotic disorder. Although the short-term outcome of UHR patients has been well researched, the long-term outcome is not known. OBJECTIVE: To assess the rate and baseline predictors of transition to psychotic disorder in UHR patients up to 15 years after study entry. DESIGN: Follow-up study of a cohort of UHR patients recruited to participate in research studies between 1993 and 2006. SETTING: The Personal Assessment and Crisis Evaluation (PACE) clinic, a specialized service for UHR patients in Melbourne, Australia. PARTICIPANTS: Four hundred sixteen UHR patients previously see..

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University of Melbourne Researchers

Hok Yuen Author Centre for Youth Mental Health

Paul Amminger Author Centre for Youth Mental Health

Daniela Cagliarini Author Centre for Youth Mental Health

Magenta Simmons Author Centre for Youth Mental Health

Stephen Wood Author Centre for Youth Mental Health

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Grants

Awarded by National Health and Medical Research Council (NHMRC) Program

Awarded by NHMRC Career Development Fellowship

Awarded by NHMRC Clinical Career Developmental Award

Awarded by NHMRC Senior Research Fellowship

Funding Acknowledgements

We acknowledge the funding support of National Health and Medical Research Council (NHMRC) Program grants 350241 and 566529 and the Colonial Foundation. Dr Nelson was supported by an NHMRC Career Development Fellowship (1027532), Dr Wood was supported by an NHMRC Clinical Career Developmental Award (359223), and Dr Yung was supported by an NHMRC Senior Research Fellowship (566593).