Journal article

Modelling and Estimation of Multicomponent T-2 Distributions

Kelvin J Layton, Mark Morelande, David Wright, Peter M Farrell, Bill Moran, Leigh A Johnston

IEEE TRANSACTIONS ON MEDICAL IMAGING | IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC | Published : 2013

Abstract

Estimation of multiple T2 components within single imaging voxels typically proceeds in one of two ways; a nonparametric grid approximation to a continuous distribution is made and a regularized nonnegative least squares algorithm is employed to perform the parameter estimation, or a parametric multicomponent model is assumed with a maximum likelihood estimator for the component estimation. In this work, we present a Bayesian algorithm based on the principle of progressive correction for the latter choice of a discrete multicomponent model. We demonstrate in application to simulated data and two experimental datasets that our Bayesian approach provides robust and accurate estimates of both t..

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