Bimodal role of Kupffer cells during colorectal cancer liver metastasis
Shu Wen Wen, Eleanor I Ager, Christopher Christophi
CANCER BIOLOGY & THERAPY | LANDES BIOSCIENCE | Published : 2013
Kupffer cells (KCs) are resident liver macrophages that play a crucial role in liver homeostasis and in the pathogenesis of liver disease. Evidence suggests KCs have both stimulatory and inhibitory functions during tumor development but the extent of these functions remains to be defined. Using KC depletion studies in an orthotopic murine model of colorectal cancer (CRC) liver metastases we demonstrated the bimodal role of KCs in determining tumor growth. KC depletion with gadolinium chloride before tumor induction was associated with an increased tumor burden during the exponential growth phase. In contrast, KC depletion at the late stage of tumor growth (day 18) decreased liver tumor load ..View full abstract
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This work was supported by Cancer Australia's Priority-driven Collaborative Cancer Research Scheme (co-funded by Cancer Australia and Cure Cancer Australia Foundation) and by the Cancer Council of Victoria. Dr Ager was supported by an NHMRC Post-doctoral Training Award. SWW was supported by an Australian Rotary Health Research Fund PhD Scholarship.