Journal article

Bimodal role of Kupffer cells during colorectal cancer liver metastasis

Shu Wen Wen, Eleanor I Ager, Christopher Christophi

CANCER BIOLOGY & THERAPY | LANDES BIOSCIENCE | Published : 2013

Abstract

Kupffer cells (KCs) are resident liver macrophages that play a crucial role in liver homeostasis and in the pathogenesis of liver disease. Evidence suggests KCs have both stimulatory and inhibitory functions during tumor development but the extent of these functions remains to be defined. Using KC depletion studies in an orthotopic murine model of colorectal cancer (CRC) liver metastases we demonstrated the bimodal role of KCs in determining tumor growth. KC depletion with gadolinium chloride before tumor induction was associated with an increased tumor burden during the exponential growth phase. In contrast, KC depletion at the late stage of tumor growth (day 18) decreased liver tumor load ..

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