Journal article

Environmental determinants of islet autoimmunity (ENDIA): a pregnancy to early life cohort study in children at-risk of type 1 diabetes

Megan AS Penno, Jennifer J Couper, Maria E Craig, Peter G Colman, William D Rawlinson, Andrew M Cotterill, Timothy W Jones, Leonard C Harrison

BMC PEDIATRICS | BMC | Published : 2013

Abstract

BACKGROUND: The incidence of type 1 diabetes has increased worldwide, particularly in younger children and those with lower genetic susceptibility. These observations suggest factors in the modern environment promote pancreatic islet autoimmunity and destruction of insulin-producing beta cells. The Environmental Determinants of Islet Autoimmunity (ENDIA) Study is investigating candidate environmental exposures and gene-environment interactions that may contribute to the development of islet autoimmunity and type 1 diabetes. METHODS/DESIGN: ENDIA is the only prospective pregnancy/birth cohort study in the Southern Hemisphere investigating the determinants of type 1 diabetes in at-risk childre..

View full abstract

Grants

Awarded by Australian National Health and Medical Research Council (NHMRC Project)


Funding Acknowledgements

This study is funded by the Australian National Health and Medical Research Council (NHMRC Project Grant 1025083). The authors wish to acknowledge the contributions of A/Prof Karen Walker (Monash University), Ms Bronwen D'Arcy (Women's and Children's Hospital), Dr Gilly Hendrie (CSIRO) and Prof Clare Collins (University of Newcastle) in the development of tools for evaluating diet and nutrition. We also acknowledge the participation of Ms Felicity Healy (Melbourne Health), Mr Wayne Soon (Princess Margaret Hospital), Ms Sherrell Cardinal (Mater Health Service), and Ms Jacki Catteau (Children's Hospital at Westmead) for the preparation of documents for ethics/research governance submissions and the local study coordinators.