Journal article
Characterization and clinical evaluation of CD10 stroma cells in the breast cancer microenvironment
C Desmedt, S Majjaj, N Kheddoumi, SK Singhal, B Haibe-Kains, F El Ouriaghli, C Chaboteaux, S Michiels, F Lallemand, F Journe, H Duvillier, S Loi, J Quackenbush, S Dekoninck, C Blanpain, L Lagneaux, N Houhou, M Delorenzi, D Larsimont, M Piccart Show all
Clinical Cancer Research | AMER ASSOC CANCER RESEARCH | Published : 2012
Abstract
Purpose: There is growing evidence that interaction between stromal and tumor cells is pivotal in breast cancer progression and response to therapy. Based on earlier research suggesting that during breast cancer progression, striking changes occur in CD10 + stromal cells, we aimed to better characterize this cell population and its clinical relevance. Experimental Design: We developed a CD10 + stroma gene expression signature (using HG U133 Plus 2.0) on the basis of the comparison of CD10 cells isolated from tumoral (n=28) and normal (n=3) breast tissue.Wefurther characterized the CD10 + cells by coculture experiments of representative breast cancer cell lines with the different CD10 + strom..
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Awarded by U.S. National Library of Medicine
Funding Acknowledgements
This project was supported by the MEDIC Foundation, Les Amis de l'Institut Bordet, the "Fonds National de la Recherche Scientifique," and the Brussels Region (Impulse Programme 2007).