Weight-Bearing Locomotion in the Developing Opossum, Monodelphis domestica following Spinal Transection: Remodeling of Neuronal Circuits Caudal to Lesion
Benjamin J Wheaton, Natassya M Noor, Sophie C Whish, Jessie S Truettner, W Dalton Dietrich, Moses Zhang, Peter J Crack, Katarzyna M Dziegielewska, Norman R Saunders
PLOS ONE | PUBLIC LIBRARY SCIENCE | Published : 2013
Complete spinal transection in the mature nervous system is typically followed by minimal axonal repair, extensive motor paralysis and loss of sensory functions caudal to the injury. In contrast, the immature nervous system has greater capacity for repair, a phenomenon sometimes called the infant lesion effect. This study investigates spinal injuries early in development using the marsupial opossum Monodelphis domestica whose young are born very immature, allowing access to developmental stages only accessible in utero in eutherian mammals. Spinal cords of Monodelphis pups were completely transected in the lower thoracic region, T10, on postnatal-day (P)7 or P28 and the animals grew to adult..View full abstract
Awarded by Victorian Neurotrauma Initiative
This work was supported by the Victorian Neurotrauma Initiative (Grant #DP049). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.