Journal article

Metalloproteomics: principles, challenges, and applications to neurodegeneration

Amber Lothian, Dominic J Hare, Rudolf Grimm, Timothy M Ryan, Colin L Masters, Blaine R Roberts

FRONTIERS IN AGING NEUROSCIENCE | FRONTIERS MEDIA SA | Published : 2013

Abstract

Trace elements are required for a variety of normal biological functions. As our understanding of neurodegenerative disease advances we are identifying a number of metalloenzymes involved in disease process. Thus, the future of metals in neurobiology will rely more on detailed information regarding what metalloenzymes are present and how they are involved in the pathophysiology of disease. To gain this detailed information, we will rely less on bulk measures of the amount of a trace elements in a particular tissue and turn to metalloproteomic techniques to help elucidate both metalloprotein structure and function. Recent advances in metalloproteomics will translate to a richer understanding ..

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Grants

Funding Acknowledgements

We would like to acknowledge funding from the Victorian Government's Operational Infrastructure Support Program, the Australian Research Council Linkage Projects Scheme (with Agilent Technologies and Kenelec Scientific), and the Australian National Health and Medical Research Council.