Metalloproteomics: principles, challenges, and applications to neurodegeneration
Amber Lothian, Dominic J Hare, Rudolf Grimm, Timothy M Ryan, Colin L Masters, Blaine R Roberts
FRONTIERS IN AGING NEUROSCIENCE | FRONTIERS MEDIA SA | Published : 2013
Trace elements are required for a variety of normal biological functions. As our understanding of neurodegenerative disease advances we are identifying a number of metalloenzymes involved in disease process. Thus, the future of metals in neurobiology will rely more on detailed information regarding what metalloenzymes are present and how they are involved in the pathophysiology of disease. To gain this detailed information, we will rely less on bulk measures of the amount of a trace elements in a particular tissue and turn to metalloproteomic techniques to help elucidate both metalloprotein structure and function. Recent advances in metalloproteomics will translate to a richer understanding ..View full abstract
We would like to acknowledge funding from the Victorian Government's Operational Infrastructure Support Program, the Australian Research Council Linkage Projects Scheme (with Agilent Technologies and Kenelec Scientific), and the Australian National Health and Medical Research Council.