Journal article
The unfolded protein response is activated in Helicobacter-induced gastric carcinogenesis in a non-cell autonomous manner
M Baird, P Woon Ang, I Clark, D Bishop, M Oshima, MC Cook, C Hemmings, S Takeishi, D Worthley, A Boussioutas, TC Wang, D Taupin
Laboratory Investigation | NATURE PUBLISHING GROUP | Published : 2013
Abstract
Mucous metaplasia (MM) is an aberrant secretory phenotype that arises during Helicobacter-induced gastric carcinogenesis. HSPA5, a key modulator of the unfolded protein response (UPR) activated by endoplasmic reticulum (ER) stress is overexpressed in gastric cancer (GC). We studied activation of the UPR in MM and GC in humans and mice. We assessed RNA and protein levels of ER stress markers (HSPA5, XBP1, and CHOP) in human GC, and correlated with Helicobacter pylori (H. pylori) status, then surveyed HSPA5 in normal gastric mucosa and gastric pre-neoplasia including gastritis and intestinal metaplasia (IM). The role of H. pylori infection in the UPR was assessed by co-culture with AGS GC cell..
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Awarded by National Health and Medical Research Council
Funding Acknowledgements
This work was supported by grants from the National Health and Medical Research Council (DT), the Canberra Hospital Radiation Oncology Trust Fund (DT), the Canberra Region Medical Foundation (DT), and ESA International (DT).