Journal article

Identification of Molecular Subtypes of Gastric Cancer With Different Responses to PI3-Kinase Inhibitors and 5-Fluorouracil

Zhengdeng Lei, Iain Beehuat Tan, Kakoli Das, Niantao Deng, Hermioni Zouridis, Sharon Pattison, Clarinda Chua, Zhu Feng, Yeoh Khay Guan, Chia Huey Ooi, Tatiana Ivanova, Shenli Zhang, Minghui Lee, Jeanie Wu, Anna Ngo, Sravanthy Manesh, Elisabeth Tan, Bin Tean Teh, Jimmy Bok Yan So, Liang Kee Goh Show all



BACKGROUND & AIMS: Almost all gastric cancers are adenocarcinomas, which have considerable heterogeneity among patients. We sought to identify subtypes of gastric adenocarcinomas with particular biological properties and responses to chemotherapy and targeted agents. METHODS: We compared gene expression patterns among 248 gastric tumors; using a robust method of unsupervised clustering, consensus hierarchical clustering with iterative feature selection, we identified 3 major subtypes. We developed a classifier for these subtypes and validated it in 70 tumors from a different population. We identified distinct genomic and epigenomic properties of the subtypes. We determined drug sensitivities..

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Awarded by Singapore National Medical Research Council, a Translational Clinical Research grant

Awarded by Ministry of Education

Awarded by Singapore Biomedical Research Council

Funding Acknowledgements

Supported by the Duke-NUS Signature Research Programs, funded by the Singapore Agency for Science, Technology, and Research, the Singapore Ministry of Health, the Singapore National Medical Research Council, a Translational Clinical Research grant (NMRC/TCR/001/2007), by the Singapore National Research Foundation and the Ministry of Education (grant CL2008-07), and by the Singapore Biomedical Research Council (grant 10/1/24/19/665).