Journal article
MYRF Is a Membrane-Associated Transcription Factor That Autoproteolytically Cleaves to Directly Activate Myelin Genes
H Bujalka, M Koenning, S Jackson, VM Perreau, B Pope, CM Hay, S Mitew, AF Hill, QR Lu, M Wegner, R Srinivasan, J Svaren, M Willingham, BA Barres, B Emery
Plos Biology | Published : 2013
Open access
Abstract
The myelination of axons is a crucial step during vertebrate central nervous system (CNS) development, allowing for rapid and energy efficient saltatory conduction of nerve impulses. Accordingly, the differentiation of oligodendrocytes, the myelinating cells of the CNS, and their expression of myelin genes are under tight transcriptional control. We previously identified a putative transcription factor, Myelin Regulatory Factor (Myrf), as being vital for CNS myelination. Myrf is required for the generation of CNS myelination during development and also for its maintenance in the adult. It has been controversial, however, whether Myrf directly regulates transcription, with reports of a transm..
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Awarded by Eunice Kennedy Shriver National Institute of Child Health and Human Development
Funding Acknowledgements
This work was supported by the Myelin Repair Foundation, grants from the Australian National Health and Medical Research Council (NHMRC project grant 1009095), Multiple Sclerosis Research Australia, the Trish Multiple Sclerosis Research Foundation, and NIH R01 EY10257 to BAB. BE is supported by a NHMRC CDF. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.