Journal article
Diffuse ventricular fibrosis is a late outcome of tachycardia-mediated cardiomyopathy after successful ablation
LH Ling, JM Kalman, AH Ellims, LM Iles, C Medi, C Sherratt, DM Kaye, JL Hare, PM Kistler, AJ Taylor
Circulation Arrhythmia and Electrophysiology | LIPPINCOTT WILLIAMS & WILKINS | Published : 2013
Abstract
Background-Successful arrhythmia ablation normalizes ejection fraction (EF) in tachycardia-mediated cardiomyopathy, but recurrent heart failure and late sudden death have been reported. The aim of this study was to characterize the left ventricle (LV) of tachycardia-mediated cardiomyopathy patients long after definitive arrhythmia cure. Methods and Results-Thirty-three patients with a history of successfully ablated incessant focal atrial tachycardia 64±36 months prior, and 20 healthy controls were recruited. At ablation, 18 patients had EF<50% (AT-low EF) that recovered within 3 months from 37±12 to 56±4% (P55% (AT-normal EF). No subjects had EF of 50% to 55%. Subjects underwent echocardiog..
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Funding Acknowledgements
Dr Ling is supported by Australian National Heart Foundation (NHF) Postgraduate Scholarship. Dr Iles is supported by Australian National Health and Medical Research Council (NHMRC) Postgraduate Research Scholarship. Dr Kaye is supported by an NHMRC program grant. Dr Hare is the recipient of a Research Investigatorship from the Cardiac Society of Australia and New Zealand. Dr Kistler is the recipient of a Research Investigatorship from the Cardiac Society of Australia and New Zealand. Dr Ellims holds a cofunded NHMRC/NHF Postgraduate Scholarship. Dr Taylor is supported by a National Health and Medical Research Council program grant, and an Australian National Heart Foundation project grant. This research is supported, in part, by the Victorian Government's Operational Infrastructure Funding. The other authors have no conflicts to report.