Journal article
Myelodysplastic syndrome incidence, transfusion dependence, health care use, and complications: An Australian population-based study 1998 to 2008
ZK McQuilten, MN Polizzotto, EM Wood, V Sundararajan
Transfusion | Published : 2013
DOI: 10.1111/trf.12054
Abstract
Background We investigated the incidence of myelodysplasia (MDS), its transfusion requirements, and complications of red blood cell (RBC) transfusion dependence (TD) using a hospitalization data set from a population of 5.3 million. Study Design and Methods This study was a retrospective cohort analysis of a population data set that captures diagnostic and procedure data on all hospitalizations from more than 300 hospitals within the Australian state of Victoria from 1998 to 2008. Results There were 3149 incident cases of MDS. The age-standardized incidence rate was higher than reported from local cancer registries (for 2007 9.6 per 100,000 [95% confidence interval {CI}, 9.2-10.0] vs. 4.8). ..
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Awarded by Australian National Health and Medical Research Council
Funding Acknowledgements
We thank Karen Botting and Debra Birznieks from the Blood Matters Project at the Victorian Department of Health for assistance with accessing the data and other resources and Damien Jolley for advice regarding the statistical methods and review of the manuscript. ZM is the recipient of an Australian National Health and Medical Research Council Postgraduate Scholarship (APP1017942). Australian Governments fully fund the Australian Red Cross Blood Service for the provision of blood products and services to the Australian community. ZM and VS planned the study, analyzed the data, and drafted the manuscript; MP and EW planned the study and drafted the manuscript. All authors approved the final manuscript.