Journal article
A novel serogenetic approach determines the community prevalence of celiac disease and informs improved diagnostic pathways
RP Anderson, MJ Henry, R Taylor, EL Duncan, P Danoy, MJ Costa, K Addison, JA Tye-Din, MA Kotowicz, RE Knight, W Pollock, GC Nicholson, BH Toh, MA Brown, JA Pasco
BMC Medicine | Published : 2013
Abstract
Background: Changing perspectives on the natural history of celiac disease (CD), new serology and genetic tests, and amended histological criteria for diagnosis cast doubt on past prevalence estimates for CD. We set out to establish a more accurate prevalence estimate for CD using a novel serogenetic approach.Methods: The human leukocyte antigen (HLA)-DQ genotype was determined in 356 patients with 'biopsy-confirmed' CD, and in two age-stratified, randomly selected community cohorts of 1,390 women and 1,158 men. Sera were screened for CD-specific serology.Results: Only five 'biopsy-confirmed' patients with CD did not possess the susceptibility alleles HLA-DQ2.5, DQ8, or DQ2.2, and four of th..
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Awarded by Geelong Region Medical Research Foundation
Funding Acknowledgements
Funding was provided by INOVA Diagnostics Inc., Nexpep Pty Ltd., the NHMRC, the Victorian Health Promotion Foundation, the Geelong Region Medical Research Foundation, the NHMRC Independent Research Institutes Infrastructure Support Scheme (grant number 361646), and Victorian State Government Operational Infrastructure Support. RPA held the Ian Mackay Fellowship from the Walter and Eliza Hall Institute and Melbourne Health; JT-D was supported by an NHMRC Postgraduate Medical Scholarship; ELD was funded by an NHMRC Career Development Award (569807); and MAB was funded by an NHMRC Senior Principal Research Fellowship. No funding bodies had any role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. The authors wish to thank the volunteers who participated in this study, and the support of Coeliac Victoria and Tasmania in volunteer recruitment.