The Hepatitis B e antigen (HBeAg) targets and suppresses activation of the Toll-like receptor signaling pathway
Tali Lang, Camden Lo, Narelle Skinner, Stephen Locarnini, Kumar Visvanathan, Ashley Mansell
Journal of Hepatology | ELSEVIER SCIENCE BV | Published : 2011
BACKGROUND & AIMS: Viruses target innate immune pathways to evade host antiviral responses. Recent studies demonstrate a relationship between hepatitis B disease states and the host's innate immune response, although the mechanism of immunomodulation is unknown. In humans, the innate immune system recognizes pathogens via pattern recognition receptors such as the Toll-like receptors (TLR), initiating anti-inflammatory responses. TLR expression and pro-inflammatory cytokine production is reduced in hepatitis B e antigen (HBeAg)-positive patients following TLR stimulation. The aim of this study was to investigate interactions between TLR signaling pathways and the mature HBeAg protein localize..View full abstract
Awarded by National Health and Medical Research Council
This project was supported by the National Health and Medical Research Council (491017) and the Victorian Government's Operational Infrastructure Support Program. T.L. was the recipient of an Australian Post-Graduate Award.