Journal article
Mycophenolate and lower graft function reduce the seroresponse of kidney transplant recipients to pandemic H1N1 vaccination
WR Mulley, K Visvanathan, AC Hurt, FG Brown, KR Polkinghorne, T Mastorakos, MC Lewicki, RL Stuart, SJ Tan, R Chean, PG Kerr, J Kanellis
Kidney International | Published : 2012
DOI: 10.1038/ki.2012.106
Abstract
In late 2009 transplant organizations recommended that kidney recipients be vaccinated for pandemic H1N1 influenza (pH1N1); however, the vaccine efficacy was unknown. We had offered a monovalent non-adjuvanted pH1N1 vaccine to transplant recipients. Here we compared the pre-and post-vaccination seroresponses of 151 transplant recipients to that of 71 hemodialysis patients and 30 healthy controls. Baseline seroprotection was similar between groups but was significantly different at 1 month (44, 56, and 87%, respectively). Seroconversion was significantly less common for transplant recipients (32%) than dialysis patients (45%) and healthy controls (77%). After adjusting for age and gender, dia..
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Funding Acknowledgements
This study and manuscript preparation received no funding from, nor was in any way influenced by, a commercial organization. The Melbourne WHO Collaborating Centre for Reference and Research on Influenza is supported by the Australian Government Department of Health and Ageing. All the authors declared no competing interests.