Journal article
Clioquinol Synergistically Augments Rescue by Zinc Supplementation in a Mouse Model of Acrodermatitis Enteropathica
J Geiser, RC de Lisle, D Finkelstein, PA Adlard, AI Bush, GK Andrews
Plos One | Published : 2013
Abstract
Background:Zinc deficiency due to poor nutrition or genetic mutations in zinc transporters is a global health problem and approaches to providing effective dietary zinc supplementation while avoiding potential toxic side effects are needed.Methods/Principal Findings:Conditional knockout of the intestinal zinc transporter Zip4 (Slc39a4) in mice creates a model of the lethal human genetic disease acrodermatitis enteropathica (AE). This knockout leads to acute zinc deficiency resulting in rapid weight loss, disrupted intestine integrity and eventually lethality, and therefore provides a model system in which to examine novel approaches to zinc supplementation. We examined the efficacy of dietar..
View full abstractGrants
Awarded by National Institute of Diabetes and Digestive and Kidney Diseases
Funding Acknowledgements
This work was supported in part by grants from the National Institutes of Health to GKA (R01 DK063975) and RCD (R01 AI 083479). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.